Anaplerotic Reactions Replinish TCA Intermediates

Anaplerotic reactions are reactions that replinish intermediates in a biochemical cycle. In the TCA cycle, Anaplerotic reactions replenish intermediates such as Succinyl CoA, Oxaloacetate, Malate, and others.


-This video explores the difference between Anaplerotic reactions and Cataplerotic Reations. Pyruvate is explored in three anaplerotic reactions producing either Acetyl CoA, Oxaloacetate, and Alpha-Ketogluterate
Odd Chain Fatty Acids can contribute to Anaplerotic reactions such as Triheptanoin conversion to Succinate.

Introduction to the TCA/Kreb's Cycle

The TriCarboxylic Acid (TCA) cycle, also known as the Citric Acid Cycle (CAC), or the Kreb's Cycle, is used extensively in every cell to produce electrons for the Electron Transport Chain (ETC).


 -This video looks at the sources of Acetyl-CoA, which feed into the TCA cycle, as well as various enzymes involved

The Fate of Pyruvate - and the theory of Atkins diet

The fate of Pyruvate are determined by the relative concentration of several downstream products as well as hormonal regulation. Oxaloacetate is an important downstream product of Pyruvate.
This video explores how Pyruvate is controlled via signalling to the enzyme Pyruvate Dehydrogenase. It also explains how the Atkins diet is supposed to work, by keeping insulin levels low, you decrease the amount of fatty acid synthesis.