01 September 2014

Pyruvate Regulation in the Starvation State

   During the Starvation State, the Liver attempts to produce Glucose for the rest of the Body. The primary source of Carbon Molecules in these new glucose molecules comes from Amino Acid Skeletons, while the Primary Energy source in the Liver is from the Oxidation of Fatty Acids into Acetyl-CoA
   To prevent Pyruvate from forming into Acetyl-CoA, the Cells have to use allosteric inhibition to stop Pyruvate Dehydrogenase (PDH) from acting on Pyruvate.

- This video explores the source of Pyruvate and Reducing Equivalents in the TCA cycle of the liver during the starvation state.
- This Video Also Explores Allosteric regulation of PDH

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