Big Picture:
An Ammonium Ion combines with Bicarbonate and Aspartate to form Urea
How is the Urea Cycle turned on and off? What might prevent the urea cycle from excreting Nitrogenous waste even when the amount of waste is very high?
The Control step:
Bicarbonate and NH4 Combine to form Carbomoyl Phosphate at the expense of 2 ATPs
Carbomoyl Phosphate Synthetase 1 (CPS1) catalyzes the reaction
If N-AcetylGlutamate (NAG) is present then CPS1 is active
NAG is formed by combining Acetyl-CoA with Glutamate
THERE MUST BE LOTS OF ACETYL-COA OR THE REACTION WON’T HAPPEN
Low energy state can prevent the Urea Cycle by not having acetyl-CoA
An Ammonium Ion combines with Bicarbonate and Aspartate to form Urea
How is the Urea Cycle turned on and off? What might prevent the urea cycle from excreting Nitrogenous waste even when the amount of waste is very high?
The Control step:
Bicarbonate and NH4 Combine to form Carbomoyl Phosphate at the expense of 2 ATPs
Carbomoyl Phosphate Synthetase 1 (CPS1) catalyzes the reaction
If N-AcetylGlutamate (NAG) is present then CPS1 is active
NAG is formed by combining Acetyl-CoA with Glutamate
THERE MUST BE LOTS OF ACETYL-COA OR THE REACTION WON’T HAPPEN
Low energy state can prevent the Urea Cycle by not having acetyl-CoA
The Urea Cycle is a vital biological process, crucial for nitrogen disposal in our bodies. This complex metabolic pathway showcases the intricacies of biochemistry, illustrating the body's remarkable ability to maintain balance. Understanding the Urea Cycle is key to appreciating the elegance of physiological systems. Informative and enlightening content.
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